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KMID : 0043319970200050491
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Archives of Pharmacal Research
1997 Volume.20 No. 5 p.491 ~ p.495
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Determination of Isoprenyl and Lavandulyl Positions of Flavonoids from Sophora flavescens by NMR Experiment
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Ryu Shi-Yong
Lee Hyun-Sun
Kim Young-Kyoon
Kim Sung-Hoon
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Abstract
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All fifteen flavonoids (1-15) have been isolated from the roots of Sophora flavescens (Leguminosae) as active principles of the cytotoxic property toward human tumor cell lines such as A549, SK-OV-3, SK-Mel-2, XF498 and HCT15, in vitro. By means of spectral analyses, particularlyby the aid of various two dimensional NMR experiments, all ad -NMR signals of 1-15 were completely assigned, and thus the structures of 1-15 were established unambiguously.
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KEYWORD
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Sophora flavescens, NMR, kushenol, COLOC, cytotoxicity, antitumor
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